Liposomes and liposome-like nanoparticles: From anti-fungal infection to the COVID-19 pandemic treatment.

The liposome is the first nanomedicine transformed into the market and applied to human patients. Since then, such phospholipid bilayer vesicles have undergone technological advancements in delivering small molecular-weight compounds and biological drugs. Numerous investigations about liposome uses were conducted in different treatment fields, including anti-tumor, anti-fungal, anti-bacterial, and clinical analgesia, owing to liposome's ability to reduce drug cytotoxicity and improve the therapeutic efficacy and combinatorial delivery. In particular, two liposomal vaccines were approved in 2021 to combat COVID-19. Herein, the clinically used liposomes are reviewed by introducing various liposomal preparations in detail that are currently proceeding in the clinic or on the market. Finally, we will discuss the challenges of developing liposomes and cutting-edge liposomal delivery for biological drugs and combination therapy.

Preparing anti-SARS-CoV-2 agent EIDD-2801 by a practical and scalable approach, and quick evaluation via machine learning.

EIDD-2801 is an orally bioavailable prodrug, which will be applied for emergency use authorization from the U.S. Food and Drug Administration for the treatment of COVID-19. To investigate the optimal parameters, EIDD-2801 was optimized via a four-step synthesis with high purity of 99.9%. The hydroxylamination procedure was telescoped in a one-pot and the final step was precisely controlled on reagents, temperature and reaction time. Compared to the original route, the yield of the new route was enhanced from 17% to 58% without column chromatography. The optimized synthesis has been successfully determinated on a decagram scale: the first step at 200 g and the final step at 20 g. Besides, the relationship between yield and temperature, time, and reagents in the deprotection step was investigated via Shapley value explanation and machine learning approach-decision tree method. The results revealed that reagents have the greatest impact on yield estimation, followed by the temperature.

Consumer Purchasing Behaviour Towards Strategic Innovation Management Practices in Morocco During COVID-19 Health Crisis

The global economy has been affected as a result of the unusual circumstances surrounding the COVID-19 outbreak and the restrictive measures taken by governments to contain the crisis. As a result, in order to survive such turmoil, sustain their economic outputs and adapt to change, companies have been invited, and even forced, to innovate. The present study aims at contributing to a better understating of the impacts of strategic innovation management (SIM) practices implemented into a company (i.e., its innovative strategy and culture, product innovation, technological capability, and customer and supplier relationships) on the consumer purchasing behaviour (CPB) in the context of COVID-19 global crisis. Data were gathered from a sample of 57 Moroccan companies operating with international management styles and working according to the standards of the International Organization for Standardization (ISO). Then, the structural equation model (SEM) method was employed to test the proposed hypothesis of the theoretical model. The conclusive results revealed that SIM practices have a significant influence on a company’s CPB, essentially via the adoption of an innovative strategy. Therefore, CPB is likely to be upgraded whenever companies seek for improving the implementation of successful SIM practices.

Service Innovation in Human Resource Management During COVID-19: A Study to Enhance Employee Loyalty Using Intrinsic Rewards.

This research focuses on the employee loyalty aspect of private hospitals in Pakistan during the COVID-19 pandemic, seriously impacted by strict work demand and work-family conflict. To manage this issue, social rewards and psychological rewards played a role as a mediator. The study uses a causal research design with a correlational study design in a non-contrived environment. Minimal researcher interference has been assured. AMOS 24 has been used to deal with the mediation in study design with bootstrap methodology. The study was conducted on 250 nurses of different private hospitals across Punjab province using a proportionate stratified sampling technique. A finding of this study suggests that nurses remain loyal to their organizations despite having uncompromising work demands and facing work-family conflict when they are provided with social and psychological rewards on their job by their organizations.